1/3/2023 0 Comments Protein scaffold trachea![]() ![]() Moreover, 3D bioprinting, one of 3D printing technologies, which uses bio-inks including cells, have recently attracted attention in organ reconstruction research. In particular, 3D printing technology using biomaterials with excellent biocompatibility and organoids using organ-specific cell aggregations have drawn attention. A bio-artificial organ is an organ made by culturing cells on a three-dimensional bio-artificial scaffold and adding growth factors. Recently, to address these obstacles, the development of bio-artificial organs based on tissue engineering technology has progressed. Even if a donor is secured and transplantation is successful, problems due to immune rejection can occur. Transplantation of donor tissues has been reported, but it is difficult to obtain adequate donor tissue. It is also accompanied by secondary damage during autologous tissue collection. However, their operation requires complex procedure such as the tissue dividing, trimming, and suturing. If the lesion is accompanied by a large tracheal stenosis and subglottic stenosis, methods such as tracheoplasty or tracheal autograft are performed. The treatment methods for the trachea are dependent on the size and length of the defect area. If a tracheal defect occurs, the mortality rate is very high therefore, various studies have been conducted to address this problem. The trachea can be damaged by stenosis, infections, trauma, congenital anomalies, and malignancies. The trachea, a tubular organ that is a conduit that connects the larynx to the lungs, plays a role in the passage of sealed and exhaled air. This novel trachea scaffold with hydrogel inside and outside of the structure was well-preserved under external flow and is expected to be advantageous for soft tissue reconstruction of the trachea. In addition, after 2 days of breathing test, the amount of gelatin remaining inside the scaffold was more than twice that of other scaffolds. In cartilage type scaffold, gelatin hydrogel printed on the outside of the scaffold was remain 22.2% under the condition where no hydrogel was left in other type scaffolds. The cartilage type showed a maximum elongation of 8 times higher than that of the bellows type and it showed the elongation of 3 times higher than that of cylinder type. A cartilage type scaffold had a highest rotational angle (254°) among them and it showed up to 2.8 times compared to human average neck rotation angle. A 250 µm-thick layer composed of polycaprolactone (PCL) nanofibers was fabricated on a rotating beam using electrospinning technology, and a scaffold with C-shaped cartilage grooves that mimics the human airway structure was printed to enable reconstruction of cartilage outside the airway. Therefore, in this study, we developed a new trachea implant with similar anatomical structure and mechanical properties to native tissue using 3D printing technology and evaluated its performance. However, current reported tubular implanting structures are difficult to impelement as replacements for original trachea movements. A trachea has a structure capable of responding to various movements such as rotation of the neck and relaxation/contraction of the conduit due to the mucous membrane and cartilage tissue. ![]()
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